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汽巴蘭3GA 號：84166-13-2  
英文名稱：Cibacron Blue 3G-A；1-Amino-4-[[4-[[4-Chloro-6-[(2-Sulfophenyl)Amino]-1,3,5-Triazin-2-Yl]Amino]-3-Sulfo-Phenyl]Amino]-9,10-Dioxo-Anthracene-2-Sulfonic Acid   
其他名稱：汽巴藍3GA；1-氨基-4-[[4-[[4--6-[(2-磺基苯基)氨基]-s-三嗪-2-基]氨基]-3-磺基-苯基]氨基]-9,10-二氧代-蒽-2-磺酸   
號：84166-13-2   
C29H20ClN7O11S3=774.16   
級別：試劑級   
性狀(以下信息僅供參考)：藍黑色粉末   
用途：本品僅供科研，不得用于其它用途   
保存：RT 客戶根據(jù)汽巴蘭3GA 號：84166-13-2 性質(zhì)、化學式、分子式、結構式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規(guī)格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產(chǎn)品化學性質(zhì)穩(wěn)定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質(zhì)。保持容器密閉。
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κB2/p52. This complex is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NKAP (NF-κ-B-activating protein) is a 415 amino acid nuclear protein that regulates TNF and IL1-induced NFκB activation. As component of a DNA-binding complex, NKAP also functions as a transcriptional repressor that acts on NOTCH target genes. Loss of NKAP blocks the development of αβT- cells, suggesting that it is required for their maturation through repression of NOTCH genes.
Function : Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
Subunit : Component of the Notch corepressor complex. Interacts with CIR1 and HDAC3.
Subcellular Location : Nucleus.
Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity : Belongs to the UPF0396 family.
Database links : UniProtKB/Swiss-Prot: Q8N5F7.1
英文名稱  Anti-NLE1
中文名稱  NLE1蛋白抗體
別    名  FLJ10458; NLE 1; Nle; Notchless gene homolog; Notchless homolog 1 (Drosophila); Notchless homolog 1; Notchless protein homolog 1; NLE1_HUMAN.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
產(chǎn)品類型  一抗   
研究領域  細胞生物 染色質(zhì)和核信號 信號轉導 
蛋白分子量  predicted molecular weight: 53kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NLE1
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.
Function : NLE1 (Notchless protein homolog 1) contains 8 WD repeats and may be involved in the Notch signaling pathway.
Subcellular Location : Nuclear, nucleolus.
Similarity : Belongs to the NLE1/RSA4 family.
Contains 8 WD repeats.
Database links : UniProtKB/Swiss-Prot: Q9NVX2.4
英文名稱  Anti-Nidogen2
中文名稱  骨巢蛋白抗體
別    名  NID 2; NID2; Nidogen2; Nidogen 2; Nidogen-2; Osteonidogen; NID2_HUMAN.
濃    度  1mg/1ml
規(guī) 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Dog, Pig, Cow, Horse
產(chǎn)品類型  一抗   
研究領域  細胞生物 神經(jīng)生物學 信號轉導 細胞周期蛋白 細胞粘附分子 細胞分化