Anti-CD45/PE-Cy7抗體說明書

Catalog Number : BYK-10602R-PE-Cy7      
Quantity size :   100ug (1mg/1ml, Buffer = 0.01M PBS, pH 7.4 with 1% BSA,0.03% Sodium azide and 50% Glycerol.)

Background:  The protein encoded by this gene is a member of the protein tyrosine

phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety

of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic

transformation. This PTP contains an extracellular domain, a single transmembrane segment

and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP.

This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an

essential regulator of T- and B-cell antigen receptor signaling. It functions through either

direct interaction with components of the antigen receptor complexes, or by activating

various Src family kinases required for the antigen receptor signaling. This PTP also

suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms,

have been reported.

Also known as: B220; CD 45; CD-45; CD45; cd45 antigen; ec3.1.3.48; CD45R; GP180;

GP180; GP 180; L CA; LCA; L-CA; Leukocyte common antigen; LY5; Ly-5 glycoprotein;

Protein tyrosine phosphatase receptor type C; Protein tyrosine phosphatase receptor type c

polypeptide; protein tyrosine phosphatase, receptor type, C; Receptor-type tyrosine-protein

phosphatase C; PTPRC; PTPRC_HUMAN; SCID due to PTPRC deficiency; T200; T200

glycoprotein; T200 leukocyte common antigen; Human homolog of severe combined

immunodeficiency due to PTPRC deficiency.

Specificity:   -Rabbit Polyclonal IgG, affinity purified by Protein A.

- PE-Cy7 conjugated

-Reacts with: Rat 

-Immunogen: KLH conjugated synthetic peptide derived from human CD45.

-Predicted molecular weight: 143kDa

Application:  Flow-Cyt=1:50-200  IF=1:50-200

             ICC=1:50-200

            Excitation spectrum: 496,594nm,743nm

            Emission spectrum: 578nm,785nm

            Optimal working dilutions must be determined by the end user.

            Protect from light.

Storage: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The Lyophilized or Liquid antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 °C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications..