LIM結(jié)構(gòu)域激酶2抗體LIM kinase 2b簡(jiǎn)單介紹：

產(chǎn)品編號(hào)：BYK-18270R

英文名稱：Anti-LIM kinase 2b
中文名稱：LIM結(jié)構(gòu)域激酶2抗體

別名：LIM containing protein kinase 2b; LIM domain kinase 2; LIM domain kinase 2b; LIM kinase 2b; LIM motif containing protein kinase 2b; LIMK 2b; LIMK-2; Limk2; LIMK2 b; LIMK2_HUMAN; LIMK2b.

背景介紹：There are approximay 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.

產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*

抗體來(lái)源 Rabbit or Mouse

克隆類型 Polyclonal or Monoclonal

交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索?。?/span>

性    狀 Lyophilized or Liquid
濃    度 1mg/ml

LIM結(jié)構(gòu)域激酶2抗體LIM kinase 2b產(chǎn)品信息：

初次體液免疫是指宿主*次接觸外來(lái)TD抗原后血清中逐漸出現(xiàn)抗原特異性抗體的過(guò)程。初次體液免疫應(yīng)答的延遲相（從抗原免疫到抗體水平達(dá)到高峰的時(shí)間）為6-10天，起初幾天血清中的抗原特異性抗體主要為親和力較低的IgM,后期以IgG為主。初次應(yīng)答過(guò)程的血清中抗原特異性抗體的高峰濃度較低且維持時(shí)間較短。再次體液免疫應(yīng)答是指曾被某抗原免疫過(guò)的宿主再次接觸該抗原時(shí)血清中迅速出現(xiàn)抗原特異性抗體的過(guò)程，其延遲相僅為4-5天，血清抗體以IgG為主，其高峰濃度較高且維持時(shí)間較長(zhǎng)。再次應(yīng)答所產(chǎn)生的抗體還有親和力成熟現(xiàn)象，即該抗體與抗原的親和力明顯高于初次應(yīng)答產(chǎn)生的抗體。

免疫應(yīng)答過(guò)程：

1.抗原進(jìn)入機(jī)體；

2.抗原刺激 B淋巴細(xì)胞，使之分化增殖成為抗體分泌漿細(xì)胞和記憶細(xì)胞（初次免疫應(yīng)答）；

3.抗體主要由漿細(xì)胞分泌 ；

4.記憶細(xì)胞再次受到特異性抗原刺激后會(huì)被激活而成為分泌抗體的漿細(xì)胞（再次免疫應(yīng)答）；

5.記憶B細(xì)胞是長(zhǎng)命細(xì)胞，可以存活數(shù)月甚至機(jī)體終生

LIM結(jié)構(gòu)域激酶2抗體LIM kinase 2b相關(guān)產(chǎn)品：

Anti-phospho-c-Abl(Tyr70) 磷酸化非受體*激酶c-Abl抗體
Anti-ZNF474/ZFP106 鋅指蛋白474抗體
Anti-RAB3GAP2 RAB3-GTP酶激活蛋白催化亞單位2抗體
Anti-ZNF307 鋅指蛋白307抗體
Anti-RAI1 維甲酸誘導(dǎo)蛋白1抗體
Anti-ZNF300 鋅指蛋白300抗體
Anti-ZNF268 鋅指脂蛋白抗體
Anti-ZNF268 鋅指脂蛋白-1c抗體
Anti-ZNF268 鋅指脂蛋白-1b抗體
Anti-ZNF217 鋅指脂蛋白217抗體
Anti-XAP2/ARA9 乙型肝炎病毒X相關(guān)蛋白2抗體
Anti-Zfp91 白血病相關(guān)新基因抗體
Anti-RDH10 *脫氫酶10抗體